Clinical Studies on Platelet Functions

Studies on Platelet Proteins

T HE IMPORTANCE of blood platelets in hemostasis is now well established.’ Many of the physiologic properties of platelets suggest the presence of a contractile protein and Bettex-Galland and L#{252}scher ( 1961 ) succeeded in isolating such a contractile protein, thrombosthenin, and studied some of its properties.24 Grette ( 1962 ) confirmed the presence of this protein in pig platelets.5 Sinc...

Studies on human platelet proteins.

D URING the last ten years evidence has been presented from different laboratories that fibrinogen may not be essential for thrombin-mediated platelet aggregation.14 Although the presence, in platelets, of a thrombinsensitive protein other than fibrinogen has been reported from this laboratory and also by other workers,5 #{176} there is no report of its isolation, structure, physicochemical pro...

Studies on human platelet gangliosides.

Gangliosides, glycosphingolipids which contain sialic acid, were studied in human platelets. They represented 0.5% of the platelet lipids and accounted for 6% of the total neuraminic acid content of platelets. Three major ganglioside fractions were identified and characterized. Ganglioside I was hematoside (G(6)) and comprised 92% of the platelet gangliosides. It contained glucose, galactose, a...

Studies on Thrombin-induced Platelet

The importance of morphologic alteration, clumping, and subsequent fusion of blood platelets in hemostasis and thrombosis is well known. The mechanisms underlying these platelet changes, often referred to as agglutination and viscous metamorphosis, are poorly understood. Since the early work of Wright and Minot (1), many studies have suggested that thrombin may be involved. Widely divergent con...

Studies on Subcellular Platelet Particles.